T-bet Runs INTERFERence

PDE8A runs interference to limit PKA inhibition of Raf-1.

Myriad extracellular and intracellular signals constantly poke or prod cells in order to influence the vast number of functions required of cells to maintain homeostasis. Selective reception of these signals and of their subsequent translation and transduction are tasks coordinated by cellular signaltransduction systems. Two of these systems, the Ras/Raf/MEK (mitogen-activated ERKkinase)/ERK ca...

Differential Localization of T-bet and Eomes

T-Bet Dependent Removal of Sin3A-Histone

Anti-proliferative Activity of T-bet

T-bet is a critical transcription factor that regulates differentiation of Th1 cells from CD4(+) precursor cells. Since T-bet directly binds to the promoter of the IFN-γ gene and activates its transcription, T-bet deficiency impairs IFN-γ production in Th1 cells. Interestingly, T-bet-deficient Th cells also display substantially augmented the production of IL-2, a T cell growth factor. Exogenou...

"T-bet"-ing on autoimmunity variants

1 Department of Microbiology and Immunology, University of California, San Francisco, California, United States of America, 2 Diabetes Center, University of California, San Francisco, California, United States of America, 3 Innovative Genomics Institute, University of California, Berkeley, California, United States of America, 4 Biomedical Sciences Graduate Program, University of California, Sa...